ABSTRACT
OBJETIVO: Avaliar a ação dos ácidos graxos de cadeia curta (AGCC) na cicatrização de anastomoses colônicas em ratos. MÉTODO: Utilizaram-se 50 ratos divididos em 4 grupos. Dois desses grupos, vinte e seis animais, foram submetidos à operação de Hartmann; metade destes (grupo HF) recebeu infusões retais diárias, no pós-operatório, de solução fisiológica a 0,9 por cento ; a outra metade (grupo HA) recebeu solução de butirato de sódio à 80mmol/l (AGCC) (HA). Os dois grupos restantes, vinte e quatro animais foram submetidos à anastomose colônica término-terminal a 4 cm da borda anal. Destes, 12 animais (grupo AF) receberam infusões retais de soro fisiológico a 0,9% e 12 animais (grupo AA) receberam a solução com AGCC. Os animais foram avaliados no 7º e 14º dia do pós-operatório. Foi realizada análise histológica da densitometria do colágeno pela coloração do sirius red, utilizando-se a microscopia de polarização com método computadorizado. RESULTADOS: Comparando-se os grupos submetidos à cirurgia de Hartmann, portanto na ausência do trânsito intestinal, observou-se concentração significativamente maior de colágeno I e total no grupo que recebeu AGCC (p=0,001). Comparando-se os grupos submetidos à anastomose término-terminal, com interferência do trânsito intestinal, não se encontrou diferença significante da concentração de colágeno I e total (p=0,056 e p=0,397, respectivamente). A ação isolada do trânsito intestinal promoveu também aumento da produção de colágeno, quando comparado ao grupo sem atuação do trânsito intestinal. CONCLUSÃO: A administração via retal de AGCC, na ausência do trânsito intestinal mostrou-se de grande valia, promovendo aumento da síntese do colágeno. Independentemente da interferência do trânsito intestinal, o principal efeito do AGCC esteve relacionado com o aumento da maturação do colágeno.
BACKGROUND: The aim of the present study was to evaluate the intraluminal effects of short chain fatty acids (SCFA) on the healing of defunctioned colon and in the presence of faecal loading in rats. METHODS: Fifty adult Wistar rats were divided in four groups. Two of them, twenty six rats, were submitted to Hartmann's procedure (HC - Hartmann Control - and HSCFA - Hartmann SCFA) and colonic anastomosis were performed in the other two groups (AC - Anastomosis Control - and ASCFA - Anastomosis SCFA). The control groups (HC and AC) received rectal infusions of saline, while the experimental groups (HSCFA and ASCFA) received the same kind of infusion but with an isosmolar solution of sodium butyrate at 80mmol/l (SCFA). The animals were sacrificed at the 7th and 14th postoperative day. Histologic preparations with sirius red staining were performed to analyse the collagen densitometry by optic microscopy with a polarized light. Collagen I, collagen III and total collagen were quantified by a computer software. RESULTS: In the groups submitted to Hartman's operation - with bowel rest - the animals submitted to rectal infusions of SCFA showed an increase in the quantity of total and collagen I. Evaluating the groups submitted to colonic anastomosis - with interference of intraluminal bulk - there was an increase in collagen I in the experimental group. The interference of the diet bowel content in the healing process, with or without SCFA rectal infusions, was analyzed crossing the groups of different surgical procedures. CONCLUSION: The main effect of rectal infusions of SCFA was related to the collagen I, either with or without interference of the intestinal bulk. The presence of diet bowel content also increased the collagen production.
ABSTRACT
OBJECTIVE: To analyze the frequency and prevalence of congenital heart defects in a tertiary care center for children with heart diseases. METHODS: We carried out an epidemiological assessment of the first medical visit of 4,538 children in a pediatric hospital from January 1995 to December 1997. All patients with congenital heart defects had their diagnoses confirmed at least on echocardiography. The frequency and prevalence of the anomalies were computed according to the classification of sequential analysis. Age, weight, and sex were compared between the groups of healthy individuals and those with congenital heart defects after distribution according to the age group. RESULTS: Of all the children assessed, 2,017 (44.4 percent) were diagnosed with congenital heart disease, 201 (4.4 percent) with acquired heart disease, 52 (1.2 percent) with arrhythmias, and 2,268 (50 percent) were healthy children. Congenital heart diseases predominated in neonates and infants, corresponding to 71.5 percent of the cases. Weight and age were significantly lower in children with congenital heart defects. Ventricular septal defect was the most frequent acyanotic anomaly, and tetralogy of Fallot was the most frequent cyanotic anomaly. CONCLUSION: Children with congenital heart defects are mainly referred during the neonatal period and infancy with impairment in gaining weight. Ventricular septal defect is the most frequent heart defect
Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Heart Defects, Congenital , Age Distribution , Brazil , Case-Control Studies , Heart Defects, Congenital , Prevalence , Retrospective Studies , Sex DistributionABSTRACT
O carcinoma inflamatório de mama, tradicionalmente, tem sido associado a um mau prognóstico devido a seu crescimento rápido, alta freqüência de metástases a distância e progressäo locorregional. O comportamento biológico do carcinoma inflamatório é sempre um desafio para os oncologistas, sendo seu tratamento multimodal. O objetivo do estudo foi a análise retrospectiva de 34 casos e a correlaçäo de variáveis clínicas e epidemiológicas com o prognóstico. Foram avaliadas 34 pacientes no período de janeiro de 1990 a dezembro de 1997, correspondendo a 1,7 porcento dos casos de câncer de mama. Os autores observaram a alta freqüência de metástases a distância e a correlaçäo do comprometimento linfonodal com essas metástases e uma sobrevida de 34,5 porcento e 20,7 porcento, em 3 e 5 anos, respectivamente